Long Covid worse than some cancers for fatigue and quality of life

Fatigue is the symptom that most significantly impacts the daily lives of long Covid patients and can affect quality of life more than some cancers, according to a new study.

The research, funded by the National Institute for Health and Care Research (NIHR), examines the impact of long Covid on the lives of over 3,750 patients who were referred to a long Covid clinic and used a digital app as part of their NHS treatment for the condition.

Patients were asked to complete questionnaires on the app about how long Covid was affecting them – considering the impact of long Covid on their day-to-day activities, levels of fatigue, depression, anxiety, breathlessness, brain fog, and their quality of life.

The researchers, led by experts from University College London (UCL) and the University of Exeter, found that many long Covid patients were seriously ill and on average had fatigue scores worse or similar to people with cancer-related anaemia or severe kidney disease.

Their health-related quality of life scores were also lower than those of people with advanced metastatic cancers, like stage IV lung cancer.

Overall, the team found the impact of long Covid on the daily activities of patients was worse than that of stroke patients and was comparable to that of patients with Parkinson’s disease.

Dr Henry Goodfellow, who co-led the study alongside the late Professor Elizabeth Murray (both UCL Institute of Epidemiology & Health), said: ‘Up to around 17% of people who get Covid go on to develop long Covid. However, the impact of the condition on patients’ day-to-day lives isn’t fully understood.

‘Our results have found that long Covid can have a devastating effect on the lives of patients – with fatigue having the biggest impact on everything from social activities to work, chores and maintaining close relationships.’

Not only does long Covid negatively impact the lives of patients on an individual level, the researchers also believe it could have a significant economic and social impact on the country.

In order to be referred to a long Covid clinic, a patient must have had symptoms in keeping with long Covid for at least 12 weeks after an acute infection.

Over 90% of long Covid patients using the app were of working age (18-65) and 51% said they had been unable to work for at least one day in the previous month, with 20 percent unable to work at all.

Meanwhile, 71% of patients were female. As working-age women make up a majority of the health and social care workforce, the impact of long Covid on their ability to function may add additional pressures to already stretched services.

According to the Office for National Statistics, around 1.4 million people in the UK had symptoms of long Covid as of July 2022. Alongside fatigue, patients typically experience breathlessness, anxiety, depression and brain fog.

Co-author Professor William Henley, of the University of Exeter Medical School, said: ‘Long Covid is an invisible condition, and many people are left trying to manage significant changes to how they can function. Shockingly, our research has revealed that long Covid can leave people with worse fatigue and quality of life than some cancers, yet the support and understanding is not at the same level.

‘We urgently need more research to enable the development of evidence-based services to support people trying to manage this debilitating new condition.’

Image: Heike Trautmann